MicroRNAs as Targets for Cancer Diagnosis: Interests and Limitations

micrornas: promising potential targets for cancer treatment

MicroRNAs as New Players for Diagnosis, Prognosis, and Therapeutic Targets in Breast Cancer

MicroRNAs are small nonprotein-coding RNAs that regulate the expressions of a wide variety of genes by sequence-specific base pairing on the 3'UTR of mRNA targets resulting in mRNA degradation or inhibition of translation. Aberrant expressions of miRNAs have been linked to tumor development, metastasis, diagnosis, prognosis, and therapy response in human breast cancer. Some miRNAs have been con...

MicroRNAs as biomarkers associated with bladder cancer

Bladder cancer is the fifth most common cancer with significant morbidity and mortality. Recently, numerous studies demonstrated that microRNAs are emerging as diagnostic biomarkers for bladder cancer. Specific miRNA profiles have been identified for several samples from patients with bladder cancer. MicroRNAs are noncoding RNA molecules of approximately 23 nucleotides that play important roles...

MicroRNAs as predictive biomarkers and therapeutic targets in prostate cancer.

Prostatectomy or irradiation is the most common traditional treatments for localized prostate cancer. In the event of recurrence and/or metastasis, androgen ablation therapy has been the mainstay treatment for many years. Although initially effective, the cancer inevitably recurs as androgen-independent PCa, a disease with limited effective treatments. Enhanced predictive biomarkers are needed ...

Micrornas as Stable Circulating Biomarkers for Lung Cancer Diagnosis

Background: Lung cancer is the leading cause of cancer mortality in the world, but there are no satisfactory biomarkers for lung cancer detection. MicroRNAs are small non-coding RNAs that regulate the gene expressions at the posttranscription level. Many microRNAs are dysregulated and shows specific expression patterns in human cancer. The aim of this study is to profile circulating microRNAs i...